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-synuclein, which happens to be a key element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which happens to be an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) strain, suggest that dysfunction of the intracellular proteinase systems, which include ubiquitin-proteasome system or lysosomal technique, which gets rid

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